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# Tamsulosin ## Overview Tamsulosin is a selective alpha-1A adrenergic receptor antagonist. ## Primary Indications * Benign prostatic hyperplasia (BPH): To improve urine flow and reduce symptoms of BPH. * Ureteral stones: To facilitate passage of kidney stones. ## Adult Dosing * **BPH:** * Standard dose: 0.4 mg orally once daily. * If inadequate response after 2-4 weeks, may increase to 0.8 mg orally once daily. * Take dose approximately 30 minutes after the same meal each day. * **Ureteral Stones:** * 0.4 mg orally once daily. May be increased to 0.8 mg orally once daily if stones do not pass. ## Pediatric Dosing Tamsulosin is not indicated for use in pediatric patients. ## Dose Adjustments * **Hepatic Impairment:** Caution is advised in mild to moderate hepatic impairment. No dose adjustment is generally needed for mild to moderate hepatic impairment. Avoid in severe hepatic impairment. ## Contraindications * Known hypersensitivity to tamsulosin or any component of the formulation. ## Adverse Effects * Dizziness, somnolence, postural hypotension, headache, ejaculation disorders (including retrograde ejaculation and anejaculation). * Intraoperative Floppy Iris Syndrome (IFIS) has been reported during cataract surgery. ## Key Drug Interactions * **CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir):** May increase tamsulosin exposure. Monitor for additive effects. * **CYP2D6 Inhibitors (e.g., paroxetine):** May increase tamsulosin exposure. Monitor for additive effects. * **Other Alpha-1 Blockers:** Concurrent use may lead to additive hypotensive effects. ## Monitoring