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# Tamsulosin ## Overview Tamsulosin is an alpha-1 adrenergic receptor antagonist. ## Primary Indications * Benign prostatic hyperplasia (BPH) - to improve urine flow and reduce symptoms. * Ureteral stones - to facilitate stone passage. ## Adult Dosing * **BPH:** The usual dose is 0.4 mg orally once daily. If inadequate response after 2-4 weeks, the dose may be increased to 0.8 mg orally once daily. Doses greater than 0.8 mg once daily are not recommended. * **Ureteral Stones:** The usual dose is 0.4 mg orally once daily. Dosing may be continued for up to 4 weeks. ## Pediatric Dosing Tamsulosin is not indicated for use in pediatric patients. ## Dose Adjustments No dose adjustment is generally required for patients with renal or hepatic impairment, though caution is advised. ## Contraindications * Known hypersensitivity to tamsulosin or any of its components. * Concomitant use with other alpha-1 adrenergic receptor antagonists. ## Adverse Effects Common adverse effects include dizziness, headache, abnormal ejaculation (including retrograde ejaculation and ejaculatory dysfunction), orthostatic hypotension, rhinitis, and diarrhea. ## Key Drug Interactions * **CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir):** May increase tamsulosin exposure and risk of adverse effects. Monitor patients closely. * **CYP2D6 Inhibitors (e.g., fluoxetine, par