Montelukast%2525252525252525252525252525252525252525252525252525252525252520levocetrizine

# Montelukast/Levocetirizine ## Overview Montelukast is a leukotriene receptor antagonist. Levocetirizine is a second-generation antihistamine. This combination is used for allergic rhinitis and chronic urticaria. ## Primary Indications * Allergic rhinitis (seasonal and perennial) * Chronic idiopathic urticaria ## Adult Dosing * **Allergic Rhinitis:** Montelukast 10 mg orally once daily plus Levocetirizine 5 mg orally once daily. * **Chronic Urticaria:** Montelukast 10 mg orally once daily plus Levocetirizine 5 mg orally once daily. ## Pediatric Dosing * **Allergic Rhinitis (6 to 11 years):** Montelukast 5 mg orally once daily plus Levocetirizine 2.5 mg orally once daily. * **Allergic Rhinitis (12 months to 5 years):** Montelukast 4 mg orally once daily. (Levocetirizine is not established in this age group as part of this combination product. Refer to individual product monographs for age-appropriate dosing of levocetirizine if required.) * **Chronic Urticaria (6 to 11 years):** Montelukast 5 mg orally once daily plus Levocetirizine 2.5 mg orally once daily. * **Chronic Urticaria (12 months to 5 years):** Montelukast 4 mg orally once daily. (Levocetirizine is not established in this age group as part of this combination product. Refer to individual product monographs for age-appropriate dosing of levocetirizine if required.) ## Dose Adjustments * **Hepatic Impairment:** Use with caution. Moderate hepatic impairment may require dose reduction of montelukast. Levocetirizine dose may need to be reduced in moderate to severe hepatic impairment. Specific recommendations vary by formulation and local guidelines; consult product monograph. * **Renal Impairment:** No dose adjustment recommended for mild to moderate renal impairment for either agent. Use with caution in severe renal impairment. ## Contraindications * Hypersensitivity to montelukast, levocetirizine, cetirizine, piper