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# Metrogyl (metronidazole) ## Overview Metronidazole is an antibiotic and antiprotozoal agent effective against anaerobic bacteria and certain parasites. ## Primary Indications * **Bacterial Vaginosis:** Treatment of bacterial vaginosis. * **Trichomoniasis:** Treatment of symptomatic trichomoniasis. * **Amebiasis:** Intestinal and extraintestinal amebiasis. * **Giardiasis:** Treatment of giardiasis. * **Anaerobic Bacterial Infections:** Treatment of serious anaerobic bacterial infections (e.g., intra-abdominal infections, skin and soft tissue infections, gynecologic infections, bone and joint infections, CNS infections, lower respiratory tract infections, endocarditis, and bacteremia). * **Pseudomembranous Colitis:** Treatment of *Clostridioides difficile*-associated diarrhea (often a second-line agent). * **Surgical Prophylaxis:** Preoperative prophylaxis in certain surgeries (e.g., colorectal surgery). ## Adult Dosing * **Bacterial Vaginosis:** * Oral: 500 mg BID for 7 days OR 2 g as a single dose. * Vaginal Gel 0.75%: 5 g intravaginally once daily for 5 days. * **Trichomoniasis:** * Oral: 2 g as a single dose OR 250 mg BID for 7 days OR 375 mg BID for 7 days. * **Amebiasis:** * Intestinal: 500-675 mg TID for 5-10 days. * Extra-intestinal (e.g., liver abscess): 500-675 mg TID for 5-10 days. * **Giardiasis:** 250 mg TID for