Please check your internet connection and try again.
# Liquid Paraffin
## Overview
Liquid paraffin is a mineral oil used as an emollient and laxative. It lubricates the intestinal tract, softening stool and easing defecation.
## Primary Indications
* Constipation
## Adult Dosing
* **Laxative:** 10 mL to 30 mL once daily, typically at bedtime. Maximum dose is generally not well-defined, but higher doses increase aspiration risk.
## Pediatric Dosing
* **Constipation:** Dosing varies by age and formulation.
* 1-5 years: 5 mL once daily.
* 6-12 years: 10 mL once daily.
* Over 12 years: Adult dosing may apply, or 10-20 mL once daily.
* *Note: Specific pediatric dosing may vary by product and should be confirmed with the product monograph or local protocol.*
## Dose Adjustments
No specific dose adjustments are typically required for renal or hepatic impairment.
## Contraindications
* Hypersensitivity to liquid paraffin.
* Concurrent use with cholecyctography agents.
* Should not be used in patients with difficulty swallowing due to the risk of aspiration and lipoid pneumonia.
* Prolonged use in children can lead to decreased absorption of fat-soluble vitamins (A, D, E, K).
## Adverse Effects
* Gastrointestinal: Abdominal cramps, nausea, vomiting, diarrhea, anal leakage.
* Long-term use: Potential for vitamin malabsorption, especially in children.
* Aspiration: Can cause lipoid pneumonia, particularly in individuals with impaired gag reflex or when taken in the supine position.
## Key Drug Interactions
* Can decrease the absorption of fat-soluble vitamins (A, D, E, K).
* Can decrease the absorption of other concurrently administered medications, particularly those that are lipid-soluble (e.g., docusate, certain anticoagulants). Separate administration by at least 2 hours.
## Monitoring
* Monitor for bowel movement frequency and consistency.
* Assess for signs of abdominal discomfort or leakage.
* In pediatric patients on prolonged therapy, monitor for signs of vitamin deficiency.
## Clinical Pearls
* Administer at bedtime to minimize daytime disruption and risk of leakage.
* Advise patients to remain upright during and for a short period after administration to reduce aspiration risk.
* Avoid use in patients with dysphagia or gastroesophageal reflux disease.
* Long-term daily use is generally discouraged; intermittent use for occasional constipation is preferred.
***
*Disclaimer: This information is intended for healthcare professionals. It is essential to verify current prescribing information from the manufacturer's official product monograph or other reliable sources before making clinical decisions.*
