Liquid%2525252525252525252525252525252525252525252525252525252520paraffin

# Liquid Paraffin ## Overview Liquid paraffin is a mineral oil that acts as an emollient and laxative. It lubricates the intestinal tract, softening stool and facilitating bowel movements. ## Primary Indications * Constipation ## Adult Dosing * **Laxative:** 10-30 mL once daily, typically at bedtime. Dosing can be adjusted based on response. Maximum of 30 mL per day. ## Pediatric Dosing * **Constipation:** Age 1-12 years: 5-10 mL once daily. Age > 12 years: Use adult dosing. * Dosing should be individualized and based on clinical response. ## Dose Adjustments No dose adjustments are typically required for renal or hepatic impairment. ## Contraindications * Appendicitis or symptoms of acute abdominal conditions. * Intestinal obstruction or impaction. * Hypersensitivity to liquid paraffin. * Use with caution in patients who have difficulty swallowing due to the risk of lipid pneumonia. ## Adverse Effects * Anal leakage, abdominal cramping, diarrhea, nausea, vomiting. * Long-term or excessive use can lead to vitamin malabsorption (fat-soluble vitamins A, D, E, K) and potential dependence. * Risk of lipid pneumonia if aspirated. ## Key Drug Interactions * **Mineral Oil:** Can decrease the absorption of fat-soluble vitamins (A, D, E, K). * **Cholestyramine:** May decrease the absorption of mineral oil. * **Other Medications:** May reduce the absorption of other orally administered drugs due to the formation of an oily barrier. Administer other medications at least 2 hours before or after liquid paraffin. ## Monitoring * Bowel movement frequency and consistency. * Signs of abdominal distension or pain. * For long-term use, consider monitoring for vitamin deficiencies. ## Clinical Pearls * Administer at bedtime to minimize daytime disruption and anal leakage. * Due to the risk of lipid pneumonia, avoid use in patients with a risk of aspiration (e.g., elderly, debilitated, those with impaired swallowing reflexes). * Do not use for prolonged periods without medical advice. * Ensure adequate fluid intake when using laxatives. *** *Disclaimer: This information is intended for healthcare professionals. Always consult the most current prescribing information and institutional guidelines before making any treatment decisions.*