Liquid%2525252525252525252525252525252525252525252525252520paraffin

# Liquid Paraffin ## Overview Liquid paraffin is a mineral oil used as a laxative. It softens the stool by lubricating the intestinal lining, preventing water absorption from the stool. ## Primary Indications Constipation. ## Adult Dosing 10-30 mL as a single dose, taken orally, usually at bedtime. Maximum once-daily dose: 30 mL. ## Pediatric Dosing * **Ages 1-5 years:** 5 mL once daily. * **Ages 6-12 years:** 10 mL once daily. * **Over 12 years:** 10-20 mL once daily. Dosing for children under 1 year should only be under strict medical supervision, generally not recommended. ## Dose Adjustments No specific dose adjustments are typically needed for hepatic or renal impairment. ## Contraindications * Abdominal pain of unknown origin. * Nausea or vomiting. * Intestinal obstruction. * Fecal impaction. * Appendicitis. * Rectal bleeding. * Difficulty swallowing (risk of aspiration). ## Adverse Effects The most common adverse effects include abdominal cramping, nausea, vomiting, diarrhea, and anal leakage. Long-term use can lead to vitamin malabsorption (fat-soluble vitamins A, D, E, K), particularly if taken with meals. Aspiration can cause lipoid pneumonia. ## Key Drug Interactions * **Cholestyramine:** May decrease the absorption of liquid paraffin. Administer them at least 2 hours apart. * **Fat-soluble vitamins (A, D, E, K):** Absorption may be reduced with chronic use. * **Other laxatives:** Concomitant use increases the risk of adverse effects, particularly electrolyte imbalance. ## Monitoring Monitor for effectiveness (bowel movements) and adverse effects (abdominal pain, cramping, anal leakage, signs of vitamin deficiency with chronic use). ## Clinical Pearls * Administer between meals or at bedtime to minimize nutrient absorption interference. * Ensure adequate fluid intake when using laxatives. * Avoid use in patients with dysphagia due to the risk of aspiration and lipoid pneumonia. * Consider alternatives for long-term management of constipation. --- *Disclaimer: This information is intended for healthcare professionals. Always consult the most current prescribing information and guidelines before administering any medication.*