Please check your internet connection and try again.
# Liquid Paraffin + Milk of Magnesia + Sodium Picosulphate
## Overview
This is a combination laxative product typically used for the relief of occasional constipation. Liquid paraffin is a lubricant laxative, milk of magnesia is an osmotic laxative, and sodium picosulphate is a stimulant laxative.
## Primary Indications
* Relief of occasional constipation.
## Adult Dosing
* **Usual Dose:** 10-15 mL once daily at bedtime.
* **Maximum Dose:** Not explicitly established for the combination, but individual components have limitations. Use should generally not exceed 7 consecutive days without medical advice.
## Pediatric Dosing
* **Children 6-12 years:** 5-10 mL once daily at bedtime.
* **Children under 6 years:** Not recommended without specific medical advice.
## Dose Adjustments
* No specific dose adjustments are typically required for renal or hepatic impairment, but caution is advised due to the potential for electrolyte imbalances with chronic use.
## Contraindications
* Ileus, intestinal obstruction, inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), appendicitis, severe abdominal pain of unknown origin, nausea, vomiting, dehydration.
* Hypersensitivity to any of the components.
## Adverse Effects
* **Common:** Abdominal cramps, diarrhea, nausea, vomiting.
* **Less Common:** Electrolyte imbalance (especially with prolonged use or overdose), rectal irritation, lipid pneumonia (from aspiration of liquid paraffin, particularly in supine patients or those with impaired gag reflex).
## Key Drug Interactions
* **Mineral oil (liquid paraffin):** Can decrease absorption of fat-soluble vitamins (A, D, E, K) and may enhance the absorption of other medications (e.g., warfarin) if taken concurrently, increasing anticoagulant effect. Separation of administration is recommended.
* **Other laxatives:** Concurrent use may lead to excessive fluid and electrolyte loss.
* **Drugs that prolong QT interval:** Potential additive effect with osmotic laxatives or magnesium-containing products.
## Monitoring
* Monitor for bowel movements and signs of dehydration or electrolyte imbalance (e.g., fatigue, muscle weakness, dizziness).
* Assess for abdominal pain or distension.
## Clinical Pearls
* This combination offers a multi-modal approach to relieving constipation.
* Administer at bedtime to promote a bowel movement the following morning.
* Ensure adequate fluid intake while using this product.
* Avoid chronic use. If constipation persists for more than 7 days, medical evaluation is necessary.
* Caution in elderly or debilitated patients and those with a risk of aspiration due to liquid paraffin.
***
**Disclaimer:** This information is intended for healthcare professionals. Always consult the official product monograph or current prescribing information for complete details and to verify dosage and safety information before administering any medication.
