Iv%252525252525252525252525252525252525252525252525252525252525252520gentamicin

## Overview Gentamicin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. It is bactericidal. ## Primary Indications * Serious infections caused by susceptible Gram-negative bacteria, including *Pseudomonas aeruginosa*, *Proteus* species, *Escherichia coli*, *Klebsiella* species, *Enterobacter* species, *Serratia* species, and *Providencia* species. * Often used in combination therapy for severe infections, such as those caused by Gram-positive organisms (e.g., enterococci, staphylococci) as a synergistic agent. * Commonly used for empiric treatment of sepsis, pneumonia, complicated urinary tract infections, intra-abdominal infections, and meningitis. ## Adult Dosing * **Traditional (Shorter) Dosing:** 1-2.5 mg/kg every 8 hours. For severe infections or serious Gram-negative infections (e.g., *Pseudomonas*), doses of 2-2.5 mg/kg may be used. * **Extended-Interval Dosing (e.g., once daily):** Preferred by some institutions due to potential for reduced toxicity and simpler administration. Doses are typically 4-7 mg/kg every 24 hours. *Specific dosing frequency and target troughs are highly dependent on local protocols and patient factors.* * **Maximum Dose:** Generally, a maximum