Ferrous%25252525252525252525252525252525252525252525252525252525252525252525252525252520ascorbate

# Ferrous Ascorbate ## Overview Ferrous ascorbate combines elemental iron with ascorbic acid. Ascorbic acid enhances iron absorption by reducing ferric iron (Fe3+) to the more readily absorbed ferrous iron (Fe2+). ## Primary Indications Treatment of iron deficiency anemia. ## Adult Dosing * **Iron Deficiency Anemia:** Dosing depends on the severity of anemia and the product's elemental iron content. A common regimen is to provide 100-200 mg of elemental iron per day, divided into 1-3 doses. Tablets typically contain 100 mg of elemental iron. Specific dosing should align with institutional protocols or guidelines from organizations like the American Society of Hematology. ## Pediatric Dosing * **Iron Deficiency Anemia Prophylaxis:** 1 mg/kg elemental iron orally once or twice daily, not to exceed 15 mg elemental iron/day. * **Iron Deficiency Anemia Treatment:** 3-6 mg/kg elemental iron orally per day, divided into 1-3 doses, not to exceed 200 mg elemental iron/day. * *Note: Exact pediatric dosing may vary based on age and weight; consult specific pediatric guidelines.* ## Dose Adjustments No specific dose adjustments are typically required for hepatic or renal impairment, but caution is advised in severe conditions due to potential for accumulation and increased gastrointestinal (GI) side effects. Monitor iron levels closely. ## Contraindications * Hemochromatosis or other causes of iron overload. * Hypersensitivity to ferrous ascorbate or its components. * Use with unabsorbed cyanocobalamin. ## Adverse Effects * **Common:** GI upset (nausea, vomiting, diarrhea, constipation, abdominal pain), dark stools. * **Serious:** Iron toxicity (especially in overdose), hypersensitivity reactions. ## Key Drug Interactions * **Antacids, Calcium Carbonate, Tetracyclines, Fluoroquinolones:** Decreased iron absorption. Separate administration by at least 2 hours. * **Levothyroxine:** Decreased absorption of both drugs. Separate administration by at least 4 hours. * **Proton Pump Inhibitors (PPIs):** May decrease iron absorption. * **Vitamin E:** May interfere with iron absorption. * **Ascorbic Acid (high doses):** May increase the risk of oxalate kidney stones. ## Monitoring * Hemoglobin and hematocrit levels. * Ferritin levels (to assess iron stores). * Symptoms of iron deficiency and iron overload. * GI side effects. ## Clinical Pearls * Administer on an empty stomach for optimal absorption, but if GI upset occurs, take with a small amount of food (avoiding dairy, eggs, and whole grains). * Concurrent administration of vitamin C (ascorbic acid) enhances iron absorption. * Dark stools are a common and expected side effect and should not be mistaken for GI bleeding. * Keep out of reach of children; iron overdose is a leading cause of poisoning deaths in young children. *** *Please note: This information is intended for educational purposes and does not substitute for professional medical advice. Always verify current prescribing information with the official drug product labeling or a qualified healthcare professional.*