Ferrous%252525252525252525252525252525252525252525252525252525252525252525252525252520ascorbate

# Ferrous Ascorbate ## Overview Ferrous ascorbate is a combination of an iron salt (ferrous) and ascorbic acid (vitamin C). Ascorbic acid enhances the absorption of non-heme iron. ## Primary Indications Treatment and prevention of iron deficiency anemia. ## Adult Dosing * **Treatment of iron deficiency anemia:** Dosing is typically based on elemental iron. Recommended doses range from **100-200 mg of elemental iron per day**, divided into 1-3 doses. * **Prevention of iron deficiency anemia:** Recommended doses range from **60-100 mg of elemental iron per day**. * **Note:** Actual ferrous ascorbate product dosing will vary based on the elemental iron content per tablet/capsule. Consult specific product labeling. ## Pediatric Dosing * Dosing is generally lower than adults and based on elemental iron. * **Treatment of iron deficiency anemia:** Dosing recommendations vary widely by age and weight, often ranging from **3-6 mg/kg/day of elemental iron**, divided into 1-3 doses, up to a maximum of **200 mg of elemental iron per day**. * **Prevention of iron deficiency anemia:** Dosing recommendations vary, often from **10-15 mg of elemental iron per day**. * **Consult pediatric guidelines or specific product information for precise dosing based on age and weight.** ## Dose Adjustments No specific dose adjustments are typically required for renal or hepatic impairment, but caution and monitoring are advised, especially in severe cases due to potential iron overload and altered metabolism. ## Contraindications * Known hypersensitivity to ferrous ascorbate. * Conditions with iron overload, such as hemochromatosis. * Certain anemias not due to iron deficiency (e.g., sideroblastic anemia, thalassemia major). ## Adverse Effects * Gastrointestinal upset is common: nausea, vomiting, constipation, diarrhea, abdominal pain, dark stools. * Iron overload can occur with prolonged excessive use. ## Key Drug Interactions * **Antacids, calcium supplements, tetracyclines, levofloxacin, ciprofloxacin, bisphosphonates, penicillamine:** Oral iron can reduce the absorption of these medications. Administer oral iron at least 2 hours before or 4-6 hours after these agents. * **Thyroid hormones:** Oral iron can reduce the absorption of thyroid hormones. Separate administration by at least 4 hours. * **Ascorbic acid:** High doses of ascorbic acid can increase the risk of oxalate kidney stones in susceptible individuals. ## Monitoring * **Hemoglobin and hematocrit:** To assess treatment efficacy. * **Reticulocyte count:** To assess bone marrow response. * **Serum ferritin and iron studies:** To assess iron stores and diagnose iron deficiency. * Monitor for signs and symptoms of gastrointestinal upset. ## Clinical Pearls * Ascorbic acid enhances iron absorption, particularly non-heme iron found in plant-based foods. * Taking ferrous ascorbate with vitamin C-rich foods or beverages (e.g., orange juice) can improve absorption. * Avoid taking with milk, eggs, or whole-grain cereals, as they can hinder absorption. * Dark stools are a common and expected side effect. * Accidental overdose of iron-containing products is a leading cause of poisoning deaths in young children; keep out of reach of children. --- ***Disclaimer:** This information is intended for healthcare professionals and does not replace the need to consult the most current prescribing information, official guidelines, and institutional protocols. Always verify drug information before making clinical decisions.*