Ferrous%25252525252525252525252525252525252525252525252525252525252525252525252520ascorbate

# Ferrous Ascorbate ## Overview Ferrous ascorbate is an oral iron supplement that combines ferrous iron with ascorbic acid (vitamin C). Ascorbic acid enhances iron absorption. ## Primary Indications Treatment and prevention of iron deficiency anemia. ## Adult Dosing * **Treatment of iron deficiency anemia:** 100 mg to 200 mg of elemental iron daily, divided into 1 to 2 doses. For example, ferrous ascorbate 100 mg twice daily provides 200 mg of elemental iron. * **Prevention of iron deficiency:** Typically 30 to 60 mg of elemental iron daily. Dosing varies based on individual risk factors and local guidelines. ## Pediatric Dosing * **Treatment of iron deficiency anemia:** Doses are based on elemental iron: 3 mg/kg/day to 6 mg/kg/day, divided into 1 to 3 doses. Maximum dose: 200 mg elemental iron per day. * **Prevention of iron deficiency:** Doses are based on elemental iron: 1 mg/kg/day to 2 mg/kg/day, not to exceed 60 mg elemental iron per day. * **Specific product dosing may vary; consult product labeling for precise pediatric formulations and doses.** ## Dose Adjustments No specific dose adjustments are typically required for hepatic or renal impairment, but caution is advised in severe cases. Monitor iron parameters closely. ## Contraindications * Known hypersensitivity to ferrous ascorbate or its components. * Hemochromatosis and other conditions of iron overload. * Hemolytic anemia where iron therapy is not indicated. ## Adverse Effects Common: * Gastrointestinal upset (nausea, vomiting, diarrhea, constipation, abdominal pain) * Black or dark stools Less common: * Allergic reactions ## Key Drug Interactions * **Antacids, calcium supplements, tetracyclines, fluoroquinolones, levothyroxine:** Decreased iron absorption. Separate administration by at least 2 hours. * **Proton pump inhibitors (PPIs):** May decrease iron absorption. * **Certain antibiotics (e.g., penicillamine, bisphosphonates):** Decreased absorption of both medications. Separate administration. ## Monitoring * Hemoglobin and hematocrit levels. * Iron studies (serum ferritin, transferrin saturation) to assess iron stores and response to therapy. * Monitor for signs and symptoms of iron overload. ## Clinical Pearls * Administer on an empty stomach to maximize absorption, but if gastric irritation occurs, take with food. * Taking with vitamin C (ascorbic acid) or citrus juice enhances absorption. * Avoid taking concurrently with milk, antacids, or certain medications that impair absorption. * Black stools are an expected and common side effect. *** **Disclaimer:** This information is intended for healthcare professionals.