Please check your internet connection and try again.
# Ferrous Ascorbate
## Overview
Ferrous ascorbate is an oral iron supplement used to treat iron deficiency anemia. It combines ferrous iron (Fe2+) with ascorbic acid (vitamin C), which enhances iron absorption.
## Primary Indications
* Treatment of iron deficiency anemia.
## Adult Dosing
* **Iron Deficiency Anemia:** Typically 100 mg to 200 mg of elemental iron daily, divided into 1 to 2 doses.
* The dose of ferrous ascorbate will vary based on the concentration of elemental iron in the specific product. For example, if a tablet contains 100 mg of elemental iron, the dose would be one tablet.
* **Maximum Dose:** Consult product labeling, but generally not to exceed 200 mg of elemental iron daily unless directed by a physician.
## Pediatric Dosing
* Dosing is highly variable based on age, weight, and the severity of iron deficiency.
* **General Recommendation:** 3 mg/kg/day of elemental iron divided into 1 to 3 doses.
* **Maximum Dose:** Consult product labeling and pediatric hematology resources. Specific pediatric formulations and doses should be used.
## Dose Adjustments
* Dose adjustments are generally not required based on renal or hepatic impairment, but caution is advised. Monitor for signs of iron overload.
## Contraindications
* Iron overload conditions (e.g., hemochromatosis).
* Hypersensitivity to iron or vitamin C.
* Anemias not due to iron deficiency (e.g., pernicious anemia, hemolytic anemia).
## Adverse Effects
* **Common:** Gastrointestinal upset (nausea, vomiting, diarrhea, constipation, abdominal pain, dark stools).
* **Serious (rare):** Iron overload, hypersensitivity reactions.
## Key Drug Interactions
* **Antacids, Calcium Supplements, Tetracyclines, Fluoroquinolones:** Decrease iron absorption. Separate administration by at least 2 hours.
* **Levothyroxine:** May decrease absorption of levothyroxine. Separate administration by at least 4 hours.
* **Penicillamine:** Decreases absorption of both drugs. Separate administration by at least 2 hours.
* **Proton Pump Inhibitors (PPIs):** May decrease iron absorption.
## Monitoring
* Hemoglobin and hematocrit levels.
* Ferritin and transferrin saturation (to assess iron stores and response).
* Signs and symptoms of iron deficiency and iron overload.
* Gastrointestinal tolerance.
## Clinical Pearls
* Administer on an empty stomach for optimal absorption, but if gastrointestinal upset occurs, take with food.
* Avoid taking with milk, antacids, coffee, or tea, as these can significantly reduce absorption.
* Ascorbic acid enhances absorption; taking with vitamin C-rich foods or a vitamin C supplement (if appropriate and recommended by a physician) can be beneficial.
* Darkening of stools is an expected and benign side effect.
* Iron overdose can be serious, especially in children. Keep out of reach of children.
***
**Disclaimer:** This information is intended for healthcare professionals. Always consult the official prescribing information or a current drug compendium for the most up-to-date and comprehensive information before making any treatment decisions. Local protocols and guidelines may also apply.
