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# Diloxanide furoate
## Overview
Diloxanide furoate is an amebicide primarily used for the treatment of asymptomatic intestinal amebiasis. It is thought to work by inhibiting protein synthesis in *Entamoeba histolytica*.
## Primary Indications
* Asymptomatic intestinal amebiasis (luminal amebiasis).
* Often used as a follow-up treatment after invasive amebiasis has been treated with an agent effective against *E. histolytica* in tissue.
## Adult Dosing
* **500 mg orally three times daily for 10 days.**
## Pediatric Dosing
* **Dosing is weight-based: 5 mg/kg orally three times daily for 10 days.**
* Maximum daily dose is typically capped at the adult dose (1.5 grams/day).
* Specific dosing guidance for neonates and infants may vary; consult local protocols.
## Dose Adjustments
* No specific dose adjustments are typically required for renal or hepatic impairment, as systemic absorption is minimal.
## Contraindications
* Known hypersensitivity to diloxanide furoate or any component of the formulation.
## Adverse Effects
* **Common:** Gastrointestinal disturbances (nausea, vomiting, abdominal pain, diarrhea, flatulence), pruritus, urticaria.
* **Less Common:** Headache, dizziness, rash.
* **Rare:** Blurred vision.
## Key Drug Interactions
* No significant drug interactions are well-established.
## Monitoring
* Clinical response: Resolution of symptoms (if any) and confirmation of parasite eradication (stool examination) may be considered, especially in certain situations or for public health reasons.
## Clinical Pearls
* Diloxanide furoate is poorly absorbed systemically, making it effective for luminal amebiasis but not for invasive disease.
* It is often combined with a tissue amebicide (e.g., metronidazole) for the treatment of invasive amebiasis to eradicate luminal cysts.
* Ensure adequate hydration during treatment.
* The taste can be unpleasant, especially for children.
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**Disclaimer:** This information is intended for healthcare professionals. Always consult the most current prescribing information and local guidelines before making any treatment decisions. Drug information can change.
