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# Diloxanide furoate
## Overview
Diloxanide furoate is an amoebicide used to treat intestinal amoebiasis. It is thought to act within the intestinal lumen.
## Primary Indications
* Asymptomatic cyst passers of *Entamoeba histolytica*.
* Intestinal amoebiasis caused by *Entamoeba histolytica*.
## Adult Dosing
* **Asymptomatic cyst passers:** 500 mg orally three times daily for 10 days.
* **Intestinal amoebiasis:** 500 mg orally three times daily for 10 days.
## Pediatric Dosing
Dosing is typically based on weight. The commonly cited dose is 20 mg/kg/day orally, divided into three doses, for 10 days. The maximum adult dose should not be exceeded. Dosage by age group:
* **Children < 1 year:** Data is limited, consult manufacturer information or specific pediatric guidelines.
* **Children 1-12 years:** 100 mg orally three times daily for 10 days.
## Dose Adjustments
No specific dose adjustments are routinely recommended for renal or hepatic impairment. However, caution may be warranted in severe disease.
## Contraindications
* Known hypersensitivity to diloxanide furoate or any component of the formulation.
* Severe hepatic impairment.
## Adverse Effects
Adverse effects are generally mild and infrequent. Common effects include:
* Nausea
* Vomiting
* Abdominal cramps
* Diarrhea
* Rash, pruritus
* Headache
* Dizziness
## Key Drug Interactions
No significant drug interactions have been well-established.
## Monitoring
* Monitor for resolution of symptoms and signs of amoebiasis.
* Stool examination for cysts may be performed to confirm eradication, though its utility varies.
## Clinical Pearls
* Diloxanide furoate is effective against the luminal trophozoite and cyst forms of *Entamoeba histolytica*.
* It is generally used for asymptomatic cyst passers or as part of combination therapy for invasive amoebiasis to ensure eradication of luminal forms.
* Absorption is poor, and its therapeutic action is primarily within the intestinal lumen.
* Always verify current prescribing information and local protocols.
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**Disclaimer:** This information is intended for healthcare professionals. It is essential to consult the official prescribing information and institutional guidelines for the most current and complete details before making any clinical decisions.
