Please check your internet connection and try again.
# Diloxanide furoate
## Overview
Diloxanide furoate is an amoebicide effective against **intestinal protozoa**, particularly *Entamoeba histolytica*. It is thought to work by inhibiting protein synthesis in amoebas. It is primarily effective against the luminal phase of infection.
## Primary Indications
* Treatment of asymptomatic **intestinal amebiasis** (amoebic cyst passers).
* Treatment of mild to moderate **intestinal amebiasis**.
## Adult Dosing
* **500 mg orally three times daily for 10 days.**
* Maximum dose: Not specifically defined, but adherence to the standard regimen is typical.
## Pediatric Dosing
* **15-20 mg/kg orally per day in three divided doses for 10 days.**
* Maximum daily dose: Not to exceed the adult dose (1500 mg/day).
* *Note: This dosing may require reconstitution of a suspension.*
## Dose Adjustments
Dose adjustments are not typically required for renal or hepatic impairment.
## Contraindications
* Known hypersensitivity to diloxanide furoate or any component of the formulation.
## Adverse Effects
* **Common:** Nausea, vomiting, diarrhea, abdominal cramps, rash, pruritus, headache.
* **Less Common:** Flatulence, dizziness, thirst.
* **Rare:** Hepatitis, urticaria.
## Key Drug Interactions
No significant drug interactions are well-documented.
## Monitoring
* Clinical response: Improvement in gastrointestinal symptoms and resolution of infection.
* Stool examination for cysts and trophozoites may be performed after treatment to confirm eradication, though this is not always routine.
## Clinical Pearls
* Diloxanide furoate is generally considered safe and well-tolerated for asymptomatic or mild intestinal amebiasis.
* It is often used as a **luminal amebicide** following treatment of invasive amebiasis with other agents to eradicate residual luminal parasites.
* It is ineffective against *E. histolytica* in **extra-intestinal sites** (e.g., liver abscess).
* The furoate ester is hydrolyzed in vivo to the active drug, diloxanide.
***
*Disclaimer: This information is intended for healthcare professionals. Always consult the most current prescribing information and local protocols before initiating or modifying drug therapy.*
