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# Bricama%25252525252525252525252525252525252525252525252525252525252520be
## Overview
Bricama%25252525252525252525252525252525252525252525252525252525252520be is a long-acting beta3-adrenergic agonist.
## Primary Indications
* Overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
## Adult Dosing
The recommended dose is 50 mg once daily.
## Pediatric Dosing
Safety and efficacy in pediatric patients have not been established.
## Dose Adjustments
No dose adjustment is necessary for patients with mild to moderate renal impairment (CrCl ≥ 30 mL/min). Use with caution in severe renal impairment.
No dose adjustment is necessary for patients with mild to moderate hepatic impairment. Use with caution in severe hepatic impairment.
## Contraindications
* Known hypersensitivity to mirabegron or any of its ingredients.
* Uncontrolled hypertension (systolic blood pressure ≥ 180 mm Hg or diastolic blood pressure ≥ 110 mm Hg).
## Adverse Effects
Common adverse effects include hypertension, nasopharyngitis, urinary tract infection, and headache.
## Key Drug Interactions
* **CYP2D6 Substrates:** Bricama%25252525252525252525252525252525252525252525252525252525252520be is a moderate inhibitor of CYP2D6. Consider dose reduction for concomitant CYP2D6 substrates with a narrow therapeutic index. Examples include metoprolol, flecainide, and thioridazine.
* **Digoxin:** Monitor digoxin levels due to potential increased exposure.
## Monitoring
* Blood pressure should be monitored regularly, especially in patients with pre-existing hypertension.
* Urinary symptom assessment.
## Clinical Pearls
* Bricama%25252525252525252525252525252525252525252525252525252525252520be can be taken with or without food.
* It may take up to 8 weeks to see the full effect of treatment.
* Due to its mechanism of action, it may cause an increase in heart rate.
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**Disclaimer:** This information is intended for healthcare professionals and does not replace the need to consult the official prescribing information or a pharmacist for the most current and complete drug details. Always verify current prescribing information before making clinical decisions.
