Amox%252520cv

# Amox%252520cv - *Likely intended:* Amoxicillin/clavulanate (Co-amoxiclav). ## Overview - Combination: amoxicillin (aminopenicillin) + clavulanate (β-lactamase inhibitor). - Broad spectrum: effective against β-lactamase-producing *H. influenzae*, *M. catarrhalis*, *S. aureus* (not MRSA), anaerobes. ## Primary Indications - Acute otitis media, sinusitis, community-acquired pneumonia. - Animal or human bite wounds, diabetic foot infections. - Intra-abdominal infections (with anaerobic coverage). ## Adult Dosing - *Mild-moderate infection:* 500 mg/125 mg every 8 hours or 875 mg/125 mg every 12 hours. - *Severe infection (e.g., pneumonia):* 875 mg/125 mg every 8 hours. - *Bite wounds:* 875 mg/125 mg every 12 hours. ## Pediatric Dosing - *Otitis media, pneumonia:* - <40 kg: 45 mg/kg/day amoxicillin component divided every 12 hours (or 40 mg/kg/day divided every 8 hours for severe). - Maximum: 1,750 mg amoxicillin/375 mg clavulanate per day. - *Dosing is based on amoxicillin component; local protocol may vary.* ## Dose Adjustments - **Renal impairment (CrCl <30 mL/min):** - Avoid 875 mg formulation. Use 500 mg every 12 hours (or every 24 hours if CrCl <10 mL/min). - **Hepatic impairment:** Caution; monitor LFTs. ## Contraindications - Penicillin allergy (anaphylaxis, urticaria). - History of cholestatic jaundice with amoxicillin/clavulanate. ## Adverse Effects - Diarrhea (common; increased with clavulanate). - Nausea, rash, vaginitis. - Rare: cholestatic hepatitis (elderly, prolonged use). ## Key Drug Interactions - Methotrexate: decreased clearance, risk of toxicity. - Oral contraceptives: potentially reduced efficacy. - Allopurinol: increased rash risk. ## Monitoring - Renal function (especially if high dose or elderly). - LFTs with prolonged therapy. - Signs of allergic reaction. ## Clinical Pearls - Better tolerated with food to reduce GI upset. - Not effective against MRSA or *Pseudomonas*. - 875 mg formulation has higher potassium content (consider in renal impairment). --- *This information is for educational purposes only and does not replace professional judgment. Always verify current dosing guidelines and prescribing information for your region.*