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# Fexofenadine
## Overview
Fexofenadine is a second-generation antihistamine that selectively antagonizes peripheral H1 receptors. It is a metabolite of terfenadine.
## Primary Indications
* Seasonal allergic rhinitis (hay fever)
* Chronic idiopathic urticaria (hives)
## Adult Dosing
* **Seasonal allergic rhinitis:** 180 mg orally once daily.
* **Chronic idiopathic urticaria:** 180 mg orally once daily.
## Pediatric Dosing
Dosing varies by age and formulation. Always consult product-specific labeling for exact pediatric dosing.
* **Children 6 to 11 years:** 30 mg orally twice daily.
* **Children 2 to 5 years:** 30 mg orally once daily. Oral suspension available.
* **Children 6 months to 2 years:** 15 mg orally twice daily with oral suspension. Specific dosing may vary based on weight and formulation.
## Dose Adjustments
* **Renal Impairment:** No dose adjustment is recommended based on available data. However, caution may be advised in severe renal impairment.
* **Hepatic Impairment:** No dose adjustment is recommended.
## Contraindications
* Hypersensitivity to fexofenadine or any component of the formulation.
## Adverse Effects
Common adverse effects include headache, dizziness, nausea, and fatigue. Generally well-tolerated.
## Key Drug Interactions
* **Antacids containing aluminum or magnesium:** May decrease fexofenadine absorption. Administer fexofenadine at least 2 hours before or 2 hours after antacids.
* **Fruit juices (e.g., grapefruit, orange, apple):** May decrease fexofenadine absorption. Avoid concurrent administration.
## Monitoring
* Monitor for therapeutic efficacy (reduction in allergic rhinitis or urticaria symptoms).
* Monitor for adverse effects.
## Clinical Pearls
* Fexofenadine is a non-sedating antihistamine, making it suitable for daytime use.
* Absorption is reduced by food and antacids; administer on an empty stomach if possible.
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**Disclaimer:** This information is intended for healthcare professionals and is based on available data. It is essential to consult the most current prescribing information and relevant guidelines for complete and up-to-date details before making any clinical decisions.
