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# Fexofenadine (Allegra)
## Overview
Fexofenadine is a second-generation antihistamine used for the symptomatic relief of allergic conditions. It is a selective peripheral H1 receptor antagonist.
## Primary Indications
* Seasonal allergic rhinitis (hay fever)
* Chronic idiopathic urticaria (hives)
## Adult Dosing
* **Seasonal allergic rhinitis:** 60 mg orally twice daily or 180 mg orally once daily.
* **Chronic idiopathic urticaria:** 60 mg orally twice daily.
## Pediatric Dosing
* **Seasonal allergic rhinitis (6-11 years):** 30 mg orally twice daily.
* **Chronic idiopathic urticaria (6-11 years):** 30 mg orally twice daily.
* **Seasonal allergic rhinitis/Chronic idiopathic urticaria (2-5 years):** 30 mg orally once daily.
* **Seasonal allergic rhinitis/Chronic idiopathic urticaria (6 months-2 years):** 15 mg orally twice daily. (Note: Suspension formulation typically used).
## Dose Adjustments
No dose adjustment is generally required for renal or hepatic impairment.
## Contraindications
Hypersensitivity to fexofenadine or its components.
## Adverse Effects
Common: Headache, dizziness, nausea, fatigue.
Less common: Somnolence, dry mouth, abdominal pain.
## Key Drug Interactions
* **Antacids containing aluminum or magnesium:** May decrease fexofenadine absorption. Separate administration by at least 2 hours.
* **Fruit juices (e.g., apple, orange, grapefruit):** May decrease fexofenadine absorption. Advise taking with water.
## Monitoring
Primarily clinical monitoring for symptom improvement and absence of adverse effects.
## Clinical Pearls
* Fexofenadine is less sedating than first-generation antihistamines.
* Onset of action is typically within 1 hour.
* Take with water; avoid fruit juices and antacids containing aluminum or magnesium.
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*This information is intended for healthcare professionals. Always verify current prescribing information and consult with a qualified provider before making any treatment decisions. Local protocols may influence dosing and management.*
