Aldactone%2525252525252525252525252525252525252525252525252525252520%2525252525252525252525252525252525252525252525252525252528spironolactone%2525252525252525252525252525252525252525252525252525252529

# Spironolactone (Aldactone) ## Overview Spironolactone is a potassium-sparing diuretic and a competitive aldosterone antagonist. ## Primary Indications * Heart failure (NYHA Class II-IV) with reduced ejection fraction * Hypertension * Edema due to heart failure, liver cirrhosis, or nephrotic syndrome * Primary hyperaldosteronism * Hirsutism in women ## Adult Dosing * **Heart Failure:** Start at 12.5-25 mg orally once daily. Titrate up to 25 mg orally