Aldactone%25252525252525252525252525252525252525252525252525252520%25252525252525252525252525252525252525252525252525252528spironolactone%25252525252525252525252525252525252525252525252525252529

# Aldactone (spironolactone) ## Overview Spironolactone is a potassium-sparing diuretic and a competitive aldosterone antagonist. ## Primary Indications * Heart failure (NYHA Class II-IV) with reduced ejection fraction * Hypertension * Edema associated with cirrhosis or nephrotic syndrome * Primary aldosteronism ## Adult Dosing * **Heart Failure:** Start at 25 mg once daily. May increase to 50 mg once daily if clinically